Strain Data Sheet

RBRC09306

Strain Information

Image
BRC No.RBRC09306
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Snap25<tm1Mtaka>
Former Common name
H-2 Haplotype
ES Cell lineE14TG2a [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.
Ohira K, Kobayashi K, Toyama K, Nakamura H K, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T
Mol. Brain, 6:12 (2013). 23497716

Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice.
Watanabe S, Yamamori S, Otsuka S, Saito M, Suzuki E, Kataoka M, Miyaoka H, Takahashi M
Epilepsy Research 115, 30-44 (2015). 26220374

A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse.
Kataoka M, Yamamori S, Suzuki E, Watanabe S, Sato T, Miyaoka H, Azuma S, Ikegami S, Kuwahara R, Suzuki-Migishima R, Nakahara Y, Nihonmatsu I, Inokuchi K, Katoh-Fukui Y, Yokoyama M, Takahashi M
PLoS One 6, e25158, (2011). 21949876

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
SV40 polyA signal2
  • congenital myasthenic syndrome 18(MedGEN)
    • Snap25synaptosomal-associated protein 252Snap25targeted mutation 1, Masami Takahashi
  • congenital myasthenic syndrome 18(MedGEN)
    • neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter)
  • congenital myasthenic syndrome 18(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal dopamine level(MP:0001905)

  • abnormal impulsive behavior control(MP:0010698)

  • abnormal locomotor behavior(MP:0001392)

  • abnormal paired-pulse facilitation(MP:0002918)

  • abnormal serotonin level(MP:0005322)
    • more 10 phenotypes
  • abnormal synaptic transmission(MP:0003635)

  • abnormal synaptic vesicle morphology(MP:0004769)

  • abnormal synaptic vesicle number(MP:0004792)

  • convulsive seizures(MP:0000947)

  • decreased neurotransmitter release(MP:0003990)

  • decreased vertical activity(MP:0002757)

  • hyperactivity(MP:0001399)

  • increased anxiety-related response(MP:0001363)

  • increased thigmotaxis(MP:0002797)

  • postnatal lethality, incomplete penetrance(MP:0011086)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Snap25 cDNA, SV40 PolyA signal, mouse phosphoglycerate kinase promoter, E. coli Neomycin resistance gene, mouse Snap25 genomic DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorMasami Takahashi (Kitasato University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data