Strain Data Sheet

RBRC09247

Strain Information

Image
BRC No.RBRC09247
TypeInbred
SpeciesMus musculus
Strain nameBALB/cHeAHiOpu
Former Common nameBALB/c, BALB/cHeOpu
H-2 Haplotype
ES Cell line
Background strainBALB/cHeAHiOpu
Appearance
Strain developmentJo Higer, The Netherlands Cancer Insitute to Masaaki Okumoto, Osaka Prefecture University before 1989. Maintained by Nobuko Mori, Osaka Prefecture University since 2005. Over 50 generation.
Strain descriptionBALB/cHeA inbred mouse strain.
Colony maintenanceSibling x Sibling
References
https://dx.doi.org/10.5772/55159

Resistance of STS/A mice to lymphoma induction by X-irradiation.
M Okumoto, R Nishikawa, S Imai, J Hilgers
J. Radiat. Res., 30, 135-139 (1989). 2769623

Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis.
N Mori, Y Matsumoto, M Okumoto, N Suzuki, J Yamate
Oncogene 20, 3609-3619 (2001). 11439324

Hemorrhagic hydrocephalus (hhy): a novel mutation on mouse chromosome 12.
Mitsuru Kuwamura, Asako Kinoshita, Masaaki Okumoto, Jyoji Yamate, Nobuko Mori
Dev. Brain Res., 152, 69-72 (2004). 15283996

Two loci controlling susceptibility to radiation-induced lymphomagenesis on mouse chromosome 4: cdkn2a, a candidate for one locus, and a novel locus distinct from cdkn2a.
Nobuko Mori
Radiat. Res., 173, 158-164 (2010). 20095847

The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice.
Tomoki Sato, Akihito Morita, Nobuko Mori, Shinji Miura
Biochem. Biophys. Res. Commun., 444, 525-530 (2014). 24472537

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ccdc85c
MGI:3644008		coiled-coil domain containing 85C12Ccdc85c<hhy>
MGI:3505575		hemorrhagic hydrocephalus
Gpd1
MGI:95679		glycerol-3-phosphate dehydrogenase 1 (soluble)15Gpd1
  • transient infantile hypertriglyceridemia and hepatosteatosis(MedGEN)
    • Prkdc
    MGI:104779    		protein kinase, DNA activated, catalytic polypeptide16Prkdc<BALB/c>
    MGI:2663729    		protein kinase, DNA activated, catalytic polypeptide; BALB/c
  • severe combined immunodeficiency due to DNA-PKcs deficiency(MedGEN)
    • Cdkn2a
    MGI:104738    		cyclin dependent kinase inhibitor 2A4Cdkn2a

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cerebellum morphology (MP:0000849)

  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal double-strand DNA break repair (MP:0010948)

  • abnormal midbrain morphology (MP:0000897)

  • abnormal nervous system morphology (MP:0003632)
    • more 10 phenotypes
  • abnormal nervous system physiology (MP:0003633)

  • abnormal occipital lobe morphology (MP:0000804)

  • cerebral aqueductal stenosis (MP:0002958)

  • dilated lateral ventricle (MP:0000825)

  • gliosis (MP:0002183)

  • hydrocephaly (MP:0001891)

  • increased apoptosis (MP:0006042)

  • increased incidence of tumors by ionizing radiation induction (MP:0004500)

  • intracranial hemorrhage (MP:0001915)

  • premature death (MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Hematological Research
    Metabolism Research
    Specific Term and ConditionsThe availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorNobuko Mori (Osaka Prefecture University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data