BRC No.RBRC09242
TypeTransgene Congenic and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameHR1.Cg-Hr<hr> Tg(EF1A-roGFP1)42Soht
Former Common nameCyto-roGFP(CROH42), HR1-hr/Cyto-roGFP
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Alexander M. Wolf, Nippon Medical School in 2012. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. The mutant mice were backcrossed to Hos:HR-1 over 10 generations.
Strain descriptionTransgenic mice expressing ratiometric redox-sensitive GFP (roGFP) in the cytosol of several tissues, including skin epidermal keratinocytes. The expression level of Tg hemizygous mice is low. Hairless mice background.
Colony maintenanceTg: Carrier x Carrier; hr: Homozygote x Homozygote [or Crossing to Hos:HR-1]
ReferencesJ. Invest. Dermatol., 134(6), 1701-1709 (2014). 24129062

Health Report

Examination Date / Room / Rack2019/09/30Room:4-BRack:G


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
CSF3human G-CSF cDNA PolyA signalUNCSF3

Gene symbolGene nameChr.Allele symbolAllele namePromoter
roGFPRedox-sensitive Green Fluorescent Protein (Jellyfish)UNroGFPhuman elongation factor 1 alpha (EF-1 alpha) promoter


Donor DNAhuman EF1A promoter, jellyfish GFP(EGFP) cDNA, human G-CSF cDNA PolyA signal
Research applicationDermatology Research
Fluorescent Proteins/lacZ System
Metabolism Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Invest. Dermatol.,134(6), 1701-1709 (2014).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorShigeo Ohta (Nippon Medical School)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.

BRC mice in Publications

No Data