RBRC09238

Information1

Image
BRC No.RBRC09238
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-CCND1)14Hzi
Former Common nameD1b14F, B6-CAG-CCND1 Tg#14
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Hirokazu Inoue, Shiga University of Medical Science and Gen Kondoh, Institute for Frontier Medical Science. The transgene was injected into the pronuclei of C57BL/6 fertilized eggs.
Strain descriptionCyclin D1b transgenic mice in which the human cyclin D1b transgene was driven by a pCAGGS promoter. Tg females develop rectal tumoers within 4 to 12 months after birth (female: 60%, male: 4%). The transgene was inserted into the intron region in chromosome 7 (7qA1).
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
ReferencesCarcinogenesis, 35, 227-236 (2014). 23975835

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
CCND1cyclin D1 (human)7CCND1CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Gene symbolGene nameChr.Allele symbolAllele namePromoter
FLAGFLAG tag (synthetic)7FLAG

Information2

Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), Human Cyclin D1b gene cDNA, FLAG-tag
Research applicationCancer Research
Cell Biology Research
Mouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHirokazu Inoue (Shiga University of Medical Science)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.

BRC mice in Publications

No Data