Strain Data Sheet

RBRC06558

Strain Information

Image
BRC No.RBRC06558
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6(D2)-Smo<Rgsc2073>
Former Common nameSmoG457X, B6-Smo/G457X
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Shigeru Makino and Yoichi Gondo, RIKEN BioResource center. Generated by RIKEN ENU-based gene driven mutagenesis. The mutant mice were backcrossed to C57BL/6J.
Strain descriptionSmo gene G457X variant mice. Homozygous mutant mice die around E10.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Gondo Y
Nat Rev Genet., 9, 803-810 (2008). 18781157

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Smosmoothened, frizzled class receptor6SmoRIKEN Genomic Sciences Center (GSC), 2073
  • basal cell carcinoma, susceptibility to, 1(MedGEN)

  • congenital hypothalamic hamartoma syndrome(MedGEN)

  • Curry-Jones syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal left-right axis patterning(MP:0001706)

  • embryonic growth retardation(MP:0003984)

  • embryonic lethality, complete penetrance(MP:0011092)

  • holoprosencephaly(MP:0005157)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Developmental Biology Research
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.)
    DepositorYoichi Gondo (RIKEN GSC)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data