Strain Data Sheet

RBRC06525

Strain Information

Image
BRC No.RBRC06525
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-Cthrc1)100Suna
Former Common nameCthrc1 Tg#100, B6-CAG-Cthrc1 Tg#100
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Sunao Takeshita, National Center for Geriatrics and Gerontology. The transgene was injected into the pronuclei of C57BL/6N fertilized eggs.
Strain descriptionCAG-Cthrc1 transgenic mice. Line 1 (RBRC06524)(1 copy). Line 100 (main line)(RBRC06525)(100 copies).
Colony maintenanceCarrier x Noncarrier [C57BL/6N]
References
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation.
Takeshita S, Fumoto T, Matsuoka K, Park K A, Aburatani H, Kato S, Ito M, Ikeda K
J Clin Invest., 123, 3914-3924 (2013). 23908115

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cthrc1collagen triple helix repeat containing 1UNCthrc1CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • Barrett esophagus(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • increased bone mass(MP:0005605)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), Mouse Cthrc1 gene cDNA
    Research applicationCancer Research
    Hematological Research
    Metabolism Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Clin. Invest., 123, 3914-3924 (2013).
    DepositorKyoji Ikeda (National Center for Geriatrics and Gerontology)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data