RBRC06494

Information1

Image
BRC No.RBRC06494
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Grm6<tm1Nak>
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Shigetada Nakanishi, Kyoto University Faculty of Medicine. CCE/EK.CCE ES cells derived from 129S/SvEv-Gpi1<c> were used to generate the mutant mice. C57BL/6 semicongenic.
Strain descriptionGrm6 gene knock-out mice. mGluR6 (glutamate receptor, metabotropic 6) gene is suggested to be responsible for ON responses in both the rod and cone systems. Homozygous mutant mice are viable and fertile. This strain is useful for investigating the promoter function of the cell-specific and developmentally regulated expression of mGluR6.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
ReferencesJ. Neurosci., 19, 2568-2579 (1999). 10087070
J. Neurosci., 17, 3014-3023 (1997). 9096137
Cell, 80, 757-765 (1995). 7889569

Health Report

Examination Date / Room / Rack2016/01/12Room:2-3Rack:A
2015/11/09Room:2-3Rack:A
2015/09/07Room:2-3Rack:A
2015/07/06Room:2-3Rack:A
2015/05/11Room:2-3Rack:A
2015/04/06Room:3-4Rack:C
2015/02/02Room:3-4Rack:C
2014/12/01Room:3-4Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
null

Information2

Donor DNAE. coli neo, herpes simplex virus thymidine kinase promoter (HSV tk promoter), mouse grm6 genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 19, 2568-2579 (1999). J. Neurosci., 17, 3014-3023 (1997). Cell, 80, 757-765 (1995).The RECIPIENT is required to obtain a prior written consent from the DEPOSITOR on use of the BIOLOGICAL RESOURCE.
DepositorShigetada Nakanishi (Kyoto University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.

BRC mice in Publications

No Data