Strain Data Sheet

RBRC06464

Strain Information

Image
BRC No.RBRC06464
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameNC.MRL-Fas<lpr>
Former Common nameNC-Lpr
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tamio Ohno, Nagoya University Graduate School of Medicine in 2014. These congenic mice were produced by 10 backcrossing of the MRL/MpJJmsSlc-lpr to the NC/JicJcl.
Strain descriptionNC/Jic congenic strain having a lpr locus from MRL/MpJ-lpr.
Colony maintenanceHomozygote x Homozygote [or Crossing to NC/JicJcl]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FasFas cell surface death receptor19Faslymphoproliferation
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • CNS inflammation(MP:0006082)

  • abnormal B cell activation(MP:0008217)

  • abnormal B cell morphology(MP:0004939)

  • abnormal B cell receptor editing(MP:0008766)

  • abnormal NK cell physiology(MP:0010766)
    • more 147 phenotypes
  • abnormal T cell morphology(MP:0008037)

  • abnormal T cell physiology(MP:0002444)

  • abnormal T cell proliferation(MP:0005094)

  • abnormal T-helper 2 physiology(MP:0005466)

  • abnormal airway responsiveness(MP:0002334)

  • abnormal cardiovascular system physiology(MP:0001544)

  • abnormal circulating protein level(MP:0005416)

  • abnormal conjunctival epithelium morphology(MP:0004481)

  • abnormal coronary artery morphology(MP:0004111)

  • abnormal cytotoxic T cell physiology(MP:0005078)

  • abnormal enzyme/coenzyme activity(MP:0005584)

  • abnormal gland morphology(MP:0002163)

  • abnormal glomerular capillary endothelium morphology(MP:0011453)

  • abnormal glomerular capillary morphology(MP:0011320)

  • abnormal hepatocyte morphology(MP:0000607)

  • abnormal immune system morphology(MP:0000685)

  • abnormal immune system organ morphology(MP:0002722)

  • abnormal immune system physiology(MP:0001790)

  • abnormal immunoglobulin level(MP:0002490)

  • abnormal interleukin level(MP:0008751)

  • abnormal kidney morphology(MP:0002135)

  • abnormal kidney physiology(MP:0002136)

  • abnormal leukocyte adhesion(MP:0003628)

  • abnormal leukocyte morphology(MP:0008246)

  • abnormal liver physiology(MP:0000609)

  • abnormal lymph node cell ratio(MP:0008828)

  • abnormal lymph node morphology(MP:0002339)

  • abnormal marginal zone B cell morphology(MP:0008180)

  • abnormal myocardium layer morphology(MP:0005329)

  • abnormal renal glomerulus basement membrane morphology(MP:0011348)

  • abnormal renal glomerulus morphology(MP:0005325)

  • abnormal skin condition(MP:0001191)

  • abnormal spatial learning(MP:0001463)

  • abnormal splenic cell ratio(MP:0008826)

  • abnormal stria vascularis morphology(MP:0000048)

  • abnormal stria vascularis vasculature morphology(MP:0004368)

  • abnormal strial intermediate cell morphology(MP:0004367)

  • abnormal submandibular gland morphology(MP:0003793)

  • abnormal thymus medulla morphology(MP:0002375)

  • abnormal thyroid follicle morphology(MP:0004696)

  • abnormal thyroid gland morphology(MP:0000681)

  • abnormal type III hypersensitivity reaction(MP:0002533)

  • abnormal vagina weight(MP:0008978)

  • albuminuria(MP:0002871)

  • autoimmune response(MP:0001844)

  • blood vessel inflammation(MP:0001863)

  • brain inflammation(MP:0001847)

  • cardiovascular system phenotype(MP:0005385)

  • conjunctivitis(MP:0001852)

  • cortical renal glomerulopathies(MP:0000523)

  • decreased B cell apoptosis(MP:0008783)

  • decreased B cell number(MP:0005017)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased IgG level(MP:0001805)

  • decreased activated T cell number(MP:0001830)

  • decreased apoptosis(MP:0006043)

  • decreased eosinophil cell number(MP:0005012)

  • decreased hepatocyte apoptosis(MP:0008891)

  • decreased immature B cell number(MP:0008215)

  • decreased interleukin-2 secretion(MP:0008688)

  • decreased macrophage apoptosis(MP:0011081)

  • decreased marginal zone B cell number(MP:0008182)

  • decreased mature B cell number(MP:0008211)

  • decreased neuron apoptosis(MP:0003204)

  • decreased spleen germinal center number(MP:0008482)

  • decreased susceptibility to autoimmune diabetes(MP:0004804)

  • decreased transitional stage B cell number(MP:0008190)

  • demyelination(MP:0000921)

  • dilated renal glomerular capsule(MP:0003670)

  • endocrine/exocrine gland phenotype(MP:0005379)

  • enlarged Peyer's patches(MP:0008136)

  • enlarged lymph nodes(MP:0000702)

  • enlarged spleen(MP:0000691)

  • enlarged thymus(MP:0000709)

  • epidermal necrosis(MP:0001220)

  • expanded mesangial matrix(MP:0011353)

  • focal hepatic necrosis(MP:0001656)

  • glomerular crescent(MP:0011506)

  • glomerulonephritis(MP:0002743)

  • impaired coordination(MP:0001405)

  • impaired leukocyte tethering or rolling(MP:0020332)

  • increased IgA level(MP:0002495)

  • increased IgG level(MP:0002493)

  • increased IgG1 level(MP:0008499)

  • increased IgG2a level(MP:0008500)

  • increased IgG2b level(MP:0008501)

  • increased IgG3 level(MP:0008502)

  • increased IgM level(MP:0002494)

  • increased anti-double stranded DNA antibody level(MP:0004762)

  • increased anti-erythrocyte antigen antibody level(MP:0004797)

  • increased anti-histone antibody level(MP:0004796)

  • increased anti-nuclear antigen antibody level(MP:0004794)

  • increased anti-single stranded DNA antibody level(MP:0004771)

  • increased apoptosis(MP:0006042)

  • increased autoantibody level(MP:0003725)

  • increased body weight(MP:0001260)

  • increased circulating serum albumin level(MP:0002965)

  • increased circulating total protein level(MP:0005568)

  • increased double-negative T cell number(MP:0005090)

  • increased follicular B cell number(MP:0008173)

  • increased gamma-delta T cell number(MP:0008346)

  • increased immature B cell number(MP:0008214)

  • increased immunoglobulin level(MP:0002461)

  • increased kidney cell proliferation(MP:0011440)

  • increased marginal zone B cell number(MP:0008181)

  • increased mesangial cell number(MP:0011427)

  • increased neutrophil cell number(MP:0000219)

  • increased or absent threshold for auditory brainstem response(MP:0011967)

  • increased plasma cell number(MP:0008097)

  • increased renal glomerulus apoptosis(MP:0011369)

  • increased renal glomerulus basement membrane thickness(MP:0011409)

  • increased spleen weight(MP:0004952)

  • increased splenocyte number(MP:0009338)

  • increased susceptibility to autoimmune disorder(MP:0005350)

  • increased susceptibility to bacterial infection(MP:0002412)

  • increased susceptibility to induced morbidity/mortality(MP:0009763)

  • increased susceptibility to systemic lupus erythematosus(MP:0004801)

  • increased susceptibility to type III hypersensitivity reaction(MP:0005615)

  • increased susceptibility to viral infection(MP:0002418)

  • increased thymus weight(MP:0004955)

  • increased transitional stage B cell number(MP:0008189)

  • increased tumor incidence(MP:0002020)

  • increased urine protein level(MP:0002962)

  • joint swelling(MP:0002936)

  • kidney failure(MP:0003606)

  • kidney inflammation(MP:0001859)

  • lacrimal gland atrophy(MP:0013455)

  • lacrimal gland inflammation(MP:0008880)

  • liver/biliary system phenotype(MP:0005370)

  • lymph node hyperplasia(MP:0008102)

  • mortality/aging(MP:0010768)

  • podocyte foot process effacement(MP:0008140)

  • premature death(MP:0002083)

  • renal cast(MP:0011402)

  • renal glomerular immunoglobulin deposits(MP:0020519)

  • renal glomerular protein deposits(MP:0020518)

  • renal glomerulus hypertrophy(MP:0011294)

  • ruffled hair(MP:0000420)

  • salivary gland inflammation(MP:0001870)

  • skin lesions(MP:0001212)

  • submandibular gland inflammation(MP:0008879)

  • thymus atrophy(MP:0003644)

  • thymus cortex atrophy(MP:0013585)

  • thyroid gland inflammation(MP:0003504)

  • vascular inflammation(MP:0001864)

  • vision/eye phenotype(MP:0005391)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For profit use of the BIOLOGICAL RESSOURCE, the RECIPIENT must contact with the Intellectual Property Office, Nagoya University to obtain a prior written consent.The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorTamio Ohno (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data