RBRC06420

Information1

Image
BRC No.RBRC06420
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameNC.Cg-Dms
Former Common nameNC.DMS, NC-Dms
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain descriptionDiabetes Mellitus Saitama, DMS. Spontaneous mutation arose in NC/Jic x KOR1 F2 generations. Heterozygous mutant mice show type 2 diabetes. Homozygous mutant mice show lethal neonatal diabetes. Under investigation (details unknown). AKR background (semicongenic) (RBRC06413), C57BL/6 background (semicongenic) (RBRC06414), BALB/c background (semicongenic) (RBRC06415), C3H background (semicongenic) (RBRC06416), DBA/2 background (semicongenic) (RBRC06417), JF1 background (semicongenic) (RBRC06418), KOR1 background(semicongenic) (RBRC06419), NC background(semicongenic) (RBRC06420).
Colony maintenanceHeterozygote x Wild-type [or Crossing to NC/NgaSlc]
References

Health Report

Examination Date / Room / Rack2020/03/30Room:4-CRack:D
2020/01/27Room:4-CRack:D
2019/11/25Room:4-CRack:D
2019/09/30Room:4-CRack:D
2019/07/29Room:4-CRack:D
2019/05/27Room:4-CRack:D
2019/03/25Room:4-CRack:D
2019/01/28Room:4-CRack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Insrinsulin receptor8Insr<Dms>diabetes mellitus saitama

Information2

Donor DNA
Research applicationDiabetes and Obesity Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 後日指定。(will be announced.)For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
DepositorYoshibumi Matsushima (Saitama Cancer Center)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Live mouse (1 to 3 months)
Additional Info.

BRC mice in Publications

No Data