Strain Data Sheet

RBRC06418

Strain Information

Image
BRC No.RBRC06418
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameJF1.Cg-Dms
Former Common nameJF.DMS, JF1-Dms
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain descriptionDiabetes Mellitus Saitama, DMS. Spontaneous mutation arose in NC/Jic x KOR1 F2 generations. Heterozygous mutant mice show type 2 diabetes. Homozygous mutant mice show lethal neonatal diabetes. Under investigation (details unknown). AKR background (semicongenic) (RBRC06413), C57BL/6 background (semicongenic) (RBRC06414), BALB/c background (semicongenic) (RBRC06415), C3H background (semicongenic) (RBRC06416), DBA/2 background (semicongenic) (RBRC06417), JF1 background (semicongenic) (RBRC06418), KOR1 background(semicongenic) (RBRC06419), NC background(semicongenic) (RBRC06420).
Colony maintenanceHeterozygote x Wild-type [or Crossing to JF1/Ms (RBRC00639)]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ednrbendothelin receptor type B14Ednrb
  • ABCD syndrome(MedGEN)

  • Donohue syndrome(DisGeNET, MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)
    • more 4 Diseases
  • hyperinsulinism due to INSR deficiency(MedGEN)

  • insulin-resistance syndrome type A(MedGEN)

  • Rabson-Mendenhall syndrome(DisGeNET, MedGEN)

  • Waardenburg syndrome type 4A(MedGEN)
    • Insrinsulin receptor8Insrdiabetes mellitus saitama
  • ABCD syndrome(MedGEN)

  • Donohue syndrome(DisGeNET, MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)
    • more 4 Diseases
  • hyperinsulinism due to INSR deficiency(MedGEN)

  • insulin-resistance syndrome type A(MedGEN)

  • Rabson-Mendenhall syndrome(DisGeNET, MedGEN)

  • Waardenburg syndrome type 4A(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    Mouse Models for Human Disease
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorYoshibumi Matsushima (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data