Strain Data Sheet

RBRC06416

Strain Information

Image
BRC No.RBRC06416
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC3.Cg-Dms
Former Common nameC3.DMS, C3H-Dms
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain descriptionDiabetes Mellitus Saitama, DMS. Spontaneous mutation arose in NC/Jic x KOR1 F2 generations. Heterozygous mutant mice show type 2 diabetes. Homozygous mutant mice show lethal neonatal diabetes. Under investigation (details unknown). AKR background (semicongenic) (RBRC06413), C57BL/6 background (semicongenic) (RBRC06414), BALB/c background (semicongenic) (RBRC06415), C3H background (semicongenic) (RBRC06416), DBA/2 background (semicongenic) (RBRC06417), JF1 background (semicongenic) (RBRC06418), KOR1 background(semicongenic) (RBRC06419), NC background(semicongenic) (RBRC06420).
Colony maintenanceHeterozygote x Wild-type [or Crossing to C3H/HeSlc]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Insr
MGI:96575		insulin receptor8Insr<Dms> diabetes mellitus saitama
  • Donohue syndrome(DisGeNET, MedGEN)

  • hyperinsulinism due to INSR deficiency(MedGEN)

  • insulin-resistance syndrome type A(MedGEN)
    • more 1 Diseases
  • Rabson-Mendenhall syndrome(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • obsolete no phenotypic analysis (MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    Mouse Models for Human Disease
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorYoshibumi Matsushima (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data