Strain Data Sheet

RBRC06413

Strain Information

Image
BRC No.RBRC06413
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameAK.Cg-Dms
Former Common nameAK.DMS, AKR-Dms
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain descriptionDiabetes Mellitus Saitama, DMS. Spontaneous mutation arose in NC/Jic x KOR1 F2 generations. Heterozygous mutant mice show type 2 diabetes. Homozygous mutant mice show lethal neonatal diabetes. Under investigation (details unknown). AKR background (semicongenic) (RBRC06413), C57BL/6 background (semicongenic) (RBRC06414), BALB/c background (semicongenic) (RBRC06415), C3H background (semicongenic) (RBRC06416), DBA/2 background (semicongenic) (RBRC06417), JF1 background (semicongenic) (RBRC06418), KOR1 background(semicongenic) (RBRC06419), NC background(semicongenic) (RBRC06420).
Colony maintenanceHeterozygote x Wild-type [or Crossing to AKR/NSlc]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Insrinsulin receptor8Insrdiabetes mellitus saitama
  • Donohue syndrome(DisGeNET, MedGEN)

  • hyperinsulinism due to INSR deficiency(MedGEN)

  • insulin-resistance syndrome type A(MedGEN)
    • more 1 Diseases
  • Rabson-Mendenhall syndrome(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    Mouse Models for Human Disease
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorYoshibumi Matsushima (Saitama Cancer Center)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data