BRC No.RBRC06408
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC;129(B6)-Siglec1<tm1(HBEGF)Mtka>
Former Common nameCD169-DTR, BALB-Siglec1/DTR KI
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. The mutant mice were crossed to BALB/c over 5 times.
Strain descriptionCD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus.
Colony maintenanceHomozygote x Homozygote [or Crossing to BALB/cAJcl]
ReferencesJ. Clin. Invest., 117, 2268-2278 (2007). 17657313

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter


Donor DNAMouse CD169 genomic DNA, E.coli Neomycin resistance gene, Human HB-EGF(DTR), Phage P1 loxP
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Biotechnol., 19, 746-750 ( 2001). J. Clin. Invest., 117, 2268-2278 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR/DEVELOPER (Masato Tanaka, Ph.D. and Kenji Kohno, Ph.D.) is requested.
DepositorMasato Tanaka (Tokyo University of Pharmacy and Life Sciences)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data