Strain Data Sheet

RBRC06404

Strain Information

Image
BRC No.RBRC06404
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Cdkn1c<tm1.1(Cdkn1b*)Kei>
Former Common namep57/p27KI, B6-Cdkn1c/Cdkn1b KI
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 5 times.
Strain descriptionp57 gene p27 knockin mice. Intron 2 of p57 was replaced with a p27 cDNA (p57<p27KI> type). Paternal imprinting gene.
Colony maintenanceHeterozygote (male) x Wild-type (female) [C57BL/6JJcl]
References
Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.
Susaki E, Nakayama K, Yamasaki L, Nakayama K I
Proc. Natl. Acad. Sci. USA, 106, 5192-5197 (2009). 19276117

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cdkn1ccyclin dependent kinase inhibitor 1C7Cdkn1ctargeted mutation 1.1, Keiichi I Nakayama
  • Beckwith-Wiedemann syndrome(DisGeNET, MedGEN)

  • IMAGe syndrome(DisGeNET, MedGEN)
    • loxPphage P1 loxP7loxP
  • Beckwith-Wiedemann syndrome(DisGeNET, MedGEN)

  • IMAGe syndrome(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal abdominal wall morphology(MP:0003257)

  • abnormal kidney papilla morphology(MP:0004193)

  • abnormal placenta morphology(MP:0001711)

  • digestive/alimentary phenotype(MP:0005381)

  • enlarged adrenal glands(MP:0000642)
    • more 8 phenotypes
  • growth/size/body region phenotype(MP:0005378)

  • hematopoietic system phenotype(MP:0005397)

  • mortality/aging(MP:0010768)

  • omphalocele(MP:0003052)

  • paternal imprinting(MP:0003123)

  • skeleton phenotype(MP:0005390)

  • uterus atresia(MP:0003568)

  • uterus atrophy(MP:0004894)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 LoxP site, mouse Cdkn1b cDNA, mouse Cdkn1c genomic DNA
    Research applicationCell Biology Research
    Cre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorKeiichi Nakayama (Kyushu University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data