Strain Data Sheet


Strain Information

BRC No.RBRC06402
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Cdkn1c<tm2.1Kei>
Former Common namep57 cKO, B6-Cdkn1c floxed
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Strain developmentDeveloped by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N6 generations).
Strain descriptionp57 floxed mice. Exons 2 to 4 were flanked by loxP sites (Flox type). Paternal imprinting gene.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
ReferencesCell Stem Cell, 9, 262-271 (2011). 21885021

Health Report

Examination Date / Room / Rack2023/08/28Room:4-CRack:G


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)7Cdkn1c<tm2.1Kei>targeted mutation 2.1, Keiichi I Nakayama

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP7loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP7loxP

Ordering Information

Donor DNAphage P1 loxP sites, mouse Cdkn1c genomic DNA
Research applicationCancer Research
Cell Biology Research
Cre/loxP system
Metabolism Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorKeiichi Nakayama (Kyushu University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

Lozano-Ureña A, Lázaro-Carot L, Jiménez-Villalba E, Montalbán-Loro R, Mateos-White I, Duart-Abadía P, Martínez-Gurrea I, Nakayama KI, Fariñas I, Kirstein M, Gil-Sanz C, Ferrón SR.
IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
Development 150(1) (2023) 36633189