BRC No.RBRC06393
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Fbxw7<tm1Kei>
Former Common name
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Strain developmentDeveloped by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 6 times.
Strain descriptionFbxw7 gene floxed mice. Exon 5 was falnked by loxP sites.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
ReferencesJ. Biol. Chem., 286, 13754-13764 (2011). 21349854
Genes & Dev., 22, 986-991 (2008). 18367647
Cancer Cell, 23, 347-361 (2013). 23518349
J Exp Med., 204, 2875-2888 (2007). 17984302
The Journal of Clinical Investigation, 121, 342-354 (2010). 21123947

Health Report

Examination Date / Room / Rack2014/12/15Room:3-BRack:H


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Fbxw7F-box and WD-40 domain protein 73Fbxw7<tm1Kei>targeted mutation 1, Keiichi I Nakayama

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP3loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP3loxP


Donor DNABacteriophage P1 LoxP sites, mouse Fbxw7 genomic DNA
Research applicationCancer Research
Cell Biology Research
Cre/loxP system
Metabolism Research
Reproductive Biology Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorKeiichi Nakayama (Kyushu University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Lab HP
Genotyping protocol -PCR-
Mouse of the Month Jan 2015

BRC mice in Publications

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