Strain Data Sheet

RBRC06385

Strain Information

Image
BRC No.RBRC06385
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Dhx15<tm1Hijo>
Former Common nameDHX15 flox, B6-Dhx15 floxed
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Hidenori Ichijo, Graduate School of Pharmaceutical Sciences, The University of Tokyo in 2012. C57BL/6 background.
Strain descriptionDhx15 floxed mice. Exon 2 was flanked by loxP sites.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
References
The DEAH-box RNA helicase DHX15 activates NF-kappaB and MAPK signaling downstream of MAVS during antiviral responses.
Mosallanejad K, Sekine Y, Ishikura-Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, Takeda K, Naguro I, Ichijo H
Sci. Signal, 7(323), ra40, 2014. 24782566

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dhx15DEAH-box helicase 155Dhx15targeted mutation 1, Hidenori Ichijo
Frtyeast FRT (flippase recombination target) site5Frt
loxPphage P1 loxP5loxP
loxPphage P1 loxP5loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased acute inflammation(MP:0005087)

  • decreased lymphocyte activation involved in immune response(MP:0020192)
    • Detailed phenotype data

    Ordering Information

    Donor DNAP1 Phage loxP sites, yeast FRT (flipase recombination target) site, mouse Dhx15 genomic DNA
    Research applicationCell Biology Research
    Cre/loxP system
    FLP/frt system
    Immunology and Inflammation Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorHidenori Ichijo (The University of Tokyo)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data