Strain Data Sheet

RBRC06324

Strain Information

Image
BRC No.RBRC06324
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(DBH-Ednrb)Ywa
Former Common nameETB KO/DBH-ETB Tg, B6-DBH-Ednrb Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. 129 and C57BL/6 mixed background.
Strain descriptionDBH-ETB transgenic mice. These mice express a Ednrb gene under the control of the human DBH promoter.
Colony maintenanceCarrier x Carrier [or Crossing to C57BL/6J(Crlj)]
References
Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice.
Murakoshi N, Miyauchi T, Kakinuma Y, Ohuchi T, Goto K, Yanagisawa M, Yamaguchi I
Circulation., 106, 1991-1998 (2002). 12370225

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
rat insulin genomic DNAUN
  • ABCD syndrome(MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)

  • Waardenburg syndrome type 4A(MedGEN)
    • mouse protamine genomic DNAUN
  • ABCD syndrome(MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)

  • Waardenburg syndrome type 4A(MedGEN)
    • Ednrbendothelin receptor type B (rat)UNEdnrbhuman Dopamine b-hydroxylase promoter
  • ABCD syndrome(MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)

  • Waardenburg syndrome type 4A(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal aorta tunica intima morphology(MP:0009872)

  • abnormal blood vessel lumen formation(MP:0020373)

  • abnormal vasodilation(MP:0001613)

  • enlarged lymphatic vessel(MP:0010200)

  • increased systemic arterial blood pressure(MP:0002842)
    • more 4 phenotypes
  • increased vasoconstriction(MP:0003025)

  • salt-sensitive hypertension(MP:0004217)

  • vascular smooth muscle hyperplasia(MP:0005489)

  • vascular stenosis(MP:0005412)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman Dopamine b-hydroxylase promoter, rat insulin genomic DNA, ET-B receptor cDNA, mouse protamine genomic DNA
    Research applicationDevelopmental Biology Research
    Hematological Research
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Circulation., 106, 1991-1998 (2002).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.
    DepositorMasashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data