Strain Data Sheet

RBRC06323

Strain Information

Image
BRC No.RBRC06323
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ednra<tm2Ywa>
Former Common nameETA flox, B6-Ednra floxed, Endothelin receptor A (ETA) conditional knockout (or Flox ETA) mouse
H-2 Haplotype
ES Cell lineNot specified (ES cell)
Background strain
Appearance
Strain developmentDeveloped by Masashi Yanagisawa, The University of Texas Southwestern Medical Center.
Strain descriptionETA (Ednra / endothelin receptor type A) gene floxed mice. Exon 6 to 7 were flanked by loxP sites.
Colony maintenanceHomozygote x Homoztgote [or Crossing to C57BL/6J(Crlj)]
References
Deletion of the endothelin-A receptor gene within the developing mandible.
Ruest L B, Kedzierski R, Yanagisawa M, Clouthier D E
Cell Tissue Res., 319, 447-453 (2005). 15647918

Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol.
Kedzierski R M, Grayburn P A, Kisanuki Y Y, Williams C S, Hammer R E, Richardson J A, Schneider M D, Yanagisawa M
Mo.l Cell Biol., 23, 8226-8232 (2003). 14585980

Health Report

Examination Date / Room / Rack2023/08/07Room:2-検Rack:C
2023/05/08Room:2-検Rack:C
2023/02/06Room:2-検Rack:C
2022/11/07Room:2-検Rack:C

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ednraendothelin receptor type A8Ednratargeted mutation 2, Masashi Yanagisawa
  • mandibulofacial dysostosis with alopecia(DisGeNET, MedGEN)

  • migraine with or without aura, susceptibility to, 1(MedGEN)
    • loxPphage P1 loxP8loxP
  • mandibulofacial dysostosis with alopecia(DisGeNET, MedGEN)

  • migraine with or without aura, susceptibility to, 1(MedGEN)
    • loxPphage P1 loxP8loxP
  • mandibulofacial dysostosis with alopecia(DisGeNET, MedGEN)

  • migraine with or without aura, susceptibility to, 1(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, mouse Ednra genomic DNA
    Research applicationCre/loxP system
    Hematological Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mo.l Cell Biol., 23, 8226-8232 (2003).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.
    DepositorMasashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data