RBRC06322

Information1

Image
BRC No.RBRC06322
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Edn1<tm1Ywa>
Former Common nameET-1 flox (ET1 flox), B6-Edn1 floxed
H-2 Haplotype
ES Cell lineSM1[129S6/SvEvTac]
Background strain
Appearance
Strain developmentDeveloped by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. SM1 ES cells were used to generate the mutant mice.
Strain descriptionET1 (Edn1 / endothelin 1) gene floxed mice. Exon 2 was flanked by loxP sites.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6J(Crlj)]
ReferencesJ. Clin. Invest., 114, 4, 504-511 (2004). 10811845
Proc. Natl. Acad. Sci. USA, 101, 2088-2093 (2004). 14764893
Hypertension 56, 121-128 (2010). 20516397

Health Report

Examination Date / Room / Rack2017/10/02Room:3-5Rack:D
2017/08/21Room:3-5Rack:D
2017/06/05Room:3-5Rack:D
2017/04/03Room:3-5Rack:D
2017/02/06Room:3-5Rack:D
2016/12/05Room:3-5Rack:D
2016/10/03Room:3-5Rack:D
2016/08/08Room:3-5Rack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Edn1endothelin 113Edn1<tm1Ywa>targeted mutation 1, Masashi Yanagisawa

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP13loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP13loxP

Information2

Donor DNAphage P1 loxP sites, mouse Edn1 genomic DNA
Research applicationCre/loxP system
Developmental Biology Research
Hematological Research
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. U S A., 101, 2088-2093 (2004).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.
DepositorMasashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data