BRC No.RBRC06321
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Ece2<tm1Ywa>
Former Common nameECE-2/C57, B6-Ece2 KO
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. SM1 ES cells were used to generate the mutant mice. The mutant mice were crossed to C57BL/6.
Strain descriptionECE-2 (Ece1 / endothelin converting enzyme 2) gene knockout mice. Exon 14 and 15 were replaced with a neomycin resistant cassette.
Colony maintenanceHeterozygote x Wild-type [C57BL/6J(Crlj)]
ReferencesJ. Clin Invest., 105, 1373-1382 (2000). 10811845

Health Report

Examination Date / Room / Rack2014/09/08Room:2-検Rack:F


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Ece2endothelin converting enzyme 216Ece2<tm1Ywa>targeted mutation 1, Masashi Yanagisawa

Gene symbolGene nameChr.Allele symbolAllele namePromoter
GHGrowth hormone polyA (Bovine)16GH

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)16mouse RNA polymerase II promoter


Donor DNAE. coli Neomycin resistance gene, mouse RNA polymerase II promoter, bovine growth hormone polyadenylation site, mouse Ece2 genomic DNA
Research applicationDevelopmental Biology Research
Hematological Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Clin Invest., 105, 1373-1382 (2000).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.
DepositorMasashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data