Strain Data Sheet

RBRC06308

Strain Information

Image
BRC No.RBRC06308
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.129-(D1Mit501-Fcgr2b) Fcgr2b<tm1Ttk>/Hros
Former Common nameKO2, B6-D1Mit501-Fcgr2b/Fcgr2b KO
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain developmentDeveloped by Sachiko Hirose, Juntendo University School of Medicine.
Strain descriptionFcgr2b gene knockout mice. This strain carries a chromosomal region of D1Mit501 to Fcgr2b derived from 129 ES cells and Fcgr2b knockout allele. Homozygous mutant mice show no obvious abnormality.
Colony maintenanceD1Mit501-Fcgr2b: Homozygote x Homozygote; Fcgr2b: Homozygote x Homozygote [or Crossing to C57BL/6NCrlCrlj]
References
Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.
Takai T, Ono M, Hikida M, Ohmori H, Ravetch J V
Nature, 379, 346-349 (1996). 8552190

Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcgamma receptor type IIb-deficient C57BL/6 genetic background.
Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
Arthritis Rheum., 63, 2930-2938 (2011). 21953083

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fcgr2bFc receptor, IgG, low affinity IIb1Fcgr2btargeted mutation 1, Toshiyuki Takai
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, mouse Fcgr2b genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Arthritis Rheum., 63, 2930-2938 (2011).
    DepositorSachiko Hirose (Juntendo University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data