Strain Information | |
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Image | |
BRC No. | RBRC06235 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | C.DS-Trpv3<Nh>/Shi |
Former Common name | BALB-Nh |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Shionogi & Co., Ltd. Arose in DS mouse that has been established as an inbred strain from a dd closed colony mice. |
Strain description | Non-hair dominant spontaneous mutant mice arose in DS/Shi inbred souse strain. A G1717A point mutation has been found in the Trpv3, which results in Gly 573 being replaced with Ser. Coisogenic strain (RBRC06233), C57BL/6J (C57BL/6JShi) congenic (RBRC06234) and BALB/c (BALB/cMsShi) congenic (RBRC06235). |
Colony maintenance | Wild-type (female) x Heterozygote (male) |
References | Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice. Haraguchi M, Hino M, Tanaka H, Maru M Exp. Anim., 46, 225-229 (1997). 9250484Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis. Hikita I, Yoshioka T, Mizoguchi T, Tsukahara K, Tsuru K, Nagai H, Hirasawa T, Tsuruta Y, Suzuki R, Ichihashi M, Horikawa T J. Dermatol. Sci., 30, 142-153 (2002). 12413770Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions. Watanabe A, Takeuchi M, Nagata M, Nakamura K, Hirasawa T, Nakao H, Makino S, Harada M Exp. Anim., 52, 77-80 (2003). 12638241Role of the Nh (Non-hair) mutation in the development of dermatitis and hyperproduction of IgE in DS-Nh mice. Watanabe A, Takeuchi M, Nagata M, Nakamura K, Nakao H, Yamashita H, Makino S, Harada M, Hirasawa T Exp. Anim., 52, 419-423 (2003). 14625409DS-Nh as an experimental model of atopic dermatitis induced by Staphylococcus aureus producing staphylococcal enterotoxin C. Yoshioka T, Hikita I, Matsutani T, Yoshida R, Asakawa M, Toyosaki-Maeda T, Hirasawa T, Suzuki R, Arimura A, Horikawa T Immunology. 108, 562-569 (2003). 12667219Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis. Yoshioka T, Hikita I, Asakawa M, Hirasawa T, Deguchi M, Matsutani T, Oku H, Horikawa T, Arimura A Immunology, 118, 293-301 (2006). 16827890Association of a mutation in TRPV3 with defective hair growth in rodents. Asakawa M, Yoshioka T, Matsutani T, Hikita I, Suzuki M, Oshima I, Tsukahara K, Arimura A, Horikawa T, Hirasawa T, Sakata T J. Invest. Dermatol., 126, 2664-2672 (2006). 16858425Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice. Yoshioka T, Imura K, Asakawa M, Suzuki M, Oshima I, Hirasawa T, Sakata T, Horikawa T, Arimura A J. Invest. Dermatol., 129, 714-722 (2009). 18754035 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Trpv3 MGI:2181407 | transient receptor potential cation channel, subfamily V, member 3 | 11 | Trpv3<Nh> MGI:2384170 | non-hair |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 6 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Immunology and Inflammation Research Mouse Models for Human Disease Sensorineural Research |
Specific Term and Conditions | 1) In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 2) The RECIPIENT must inform the DEPOSITOR the research plan using the BIOLOGICAL RESOURCE and must obtain a prior written consent form the DEPOSITOR using the APPROVAL FORM specified by the DEPOSITOR. 3) The RECIPIENT shall use the BIOLOGICAL RESOURCE exclusively for the purpose of research which was written in the research plan. 4) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must inform the DEPOSITOR of the contents of such publication in advance. 5) The RECIPIENT contact and discuss with the DEPOSITOR in case of filing a patent application based on research results by using the BIOLOGICAL RESOURCES. 6) The RECIPIENT must contact and discuss with the DEPOSITOR in case of application for any commercial use. |
Depositor | Kiyoshi Yasui (Shionogi & Co., Ltd) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |