RBRC06231

Information1

Image
BRC No.RBRC06231
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Bcl11b<tm1Jpk>
Former Common nameB6-Bcl11b KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Ryo Kominami, Graduate School of Medical and Dental Science, Niigata University. TT2 ES cells derived from B6CBAF1 were used for the generation of knockout mice. C57BL/6 background (RBRC06231), BALB/c background (RBRC02421).
Strain descriptionBcl11b gene knock-out mice. A PGK-neo cassette was inserted into exon 1 of the Bcl11b gene. Bcl11b is a tumor-suppressor gene involved in T cell lymphomas. Homozygous mutant mice diw within the first day after birth. Mutant mice show a block at the CD4-CD8 double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. C57BL/6 background (RBRC06231), BALB/c background (RBRC02421).
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesNat. Immunol., 4, 533-539 (2003). 12717433

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Bcl11bB cell leukemia/lymphoma 11B12Bcl11b<tm1Jpk>targeted mutation 1, Japan Kominami

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)12mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Bcl11b genomic DNA
Research applicationCancer Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 4, 533-539 (2003).The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorRyo Kominami (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data