Strain Data Sheet

RBRC06221

update : 2026-01-20

Strain Information
Image
BRC No.	RBRC06221
Type	Targeted Mutation
Species	Mus musculus
Strain name	B6;129-Slc39a10<tm1.1Tfk>
Former Common name	ZIP10 floxed, B6-Slc39a10 floxed
H-2 Haplotype
ES Cell line	R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain development	Developed by Toshiyuki Fukuda, RIKEN Center for Allergy and Immunology in 2013. R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1-Kitl<+> were used for the generation of floxed mice. The mutant mice were crossed to C57BL/6J over 9 times.
Strain description	Zip10 (Slc39a10) gene floxed mice. Exons from 6 to 8 were flanked by loxP sites.
Colony maintenance	Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
References	Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, Bin B H, Irie T, Tanaka J, Atsumi T, Murakami M, Nakayama M, Ohara O, Himeno S, Yoshida H, Koseki H, Ikawa T, Mishima K, Fukada T Proc. Natl. Acad. Sci. USA, 111:11786-11791 (2014). 25074919 Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Miyai T, Hojyo S, Ikawa T, Kawamura M, Irie T, Ogura H, Hijikata A, Bin B H, Yasuda T, Kitamura H, Nakayama M, Ohara O, Yoshida H, Koseki H, Mishima K, Fukada T Proc. Natl. Acad. Sci. USA, 111:11780-11785 (2014). 25074913 Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis. Bin B H, Bhin J, Takaishi M, Toyoshima K E, Kawamata S, Ito K, Hara T, Watanabe T, Irie T, Takagishi T, Lee S H, Jung H S, Rho S, Seo J, Choi D H, Hwang D, Koseki H, Ohara O, Sano S, Tsuji T, Mishima K, Fukada T Proc. Natl. Acad. Sci. USA, 114:12243-12248 (2017). 29078349

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Slc39a10 MGI:1914515	solute carrier family 39 (zinc transporter), member 10	1	Slc39a10<tm1.1Tfk> MGI:5642299	targeted mutation 1.1, Toshiyuki Fukada
loxP	phage P1 loxP	1	loxP
loxP	phage P1 loxP	1	loxP

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	normal phenotype (MP:0002873)
Detailed phenotype data

Ordering Information
Donor DNA	Enterobacteria phage P1 loxP sites, mouse Slc39a10 genomic DNA
Research application	Cre/loxP system Developmental Biology Research
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 114(46):12243-12248 (2017). Proc. Natl. Acad. Sci. USA, 111, 11786-11791 (2014). Proc. Natl. Acad. Sci. USA, 111, 11780-11785 (2014). Prior to requesting the BIOLOGICAL RESOURCE, the Recipient shall contact with the Developer scientist (Dr. Toshiyuki Fukada, Tokushima Bunri University, email: fukada@ph.bunri-u.ac.jp) and obtain the use permission.
Depositor	Drs. Shigeo Koyasu and Toshiyuki Fukada (RIKEN)
Strain Status	Frozen embryos Frozen sperm
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month)
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English) Genotyping protocol -PCR-

BRC mice in Publications

Kawata Y, Terakawa J, Takeshita A, Namiki T, Kageyama A, Noguchi M, Murakami H, Fukada T, Ito J, Kashiwazaki N. Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice. PNAS Nexus 4(2) pgaf047(2025) 39967682
Atsuko Kageyama, Narumi Ogonuki, Takuya Wakai, Takafumi Namiki, Yui Kawata, Manabu Ozawa, Yasuhiro Yamada, Toshiyuki Fukada, Atsuo Ogura, Rafael A Fissore, Naomi Kashiwazaki, Junya Ito The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice eLife (2025)