RBRC06217

Information1

Image
BRC No.RBRC06217
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Slc39a13<tm1Thir>
Former Common nameZIP13 KO, B6-Slc39a13 KO
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain developmentDeveloped by Toshiyuki Fukuda, RIKEN Center for Allergy and Immunology in 2008. R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1-Kitl<+> were used for the generation of knockout mice. The mutant mice were crossed to C57BL/6J.
Strain descriptionZip13 (Slc39a13) gene knockout mice. Exons 6 through 8 were replaced with a neo cassette.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesPLoS Genet. 2017 Aug 30;13(8):e1006950. doi: 10.1371/journal.pgen.1006950. eCollection 2017 Aug. 28854265
PLoS One. 2008 3(11):e3642. 18985159

Health Report

Examination Date / Room / Rack2017/03/27Room:4-ARack:F
2017/01/30Room:4-ARack:F
2017/01/23Room:4-ARack:F
2016/11/28Room:4-ARack:F
2016/09/26Room:4-ARack:F
2016/07/25Room:4-ARack:F
2016/06/27Room:4-ARack:F
2016/06/17Room:4-ARack:F

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Slc39a13solute carrier family 39 (metal ion transporter), member 132Slc39a13<tm1Thir>targeted mutation 1, Toshio Hirano

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Slc39a13 genomic DNA
Research applicationDermatology Research
Developmental Biology Research
Mouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One. 2008 3(11):e3642.
DepositorDrs. Shigeo Koyasu and Toshiyuki Fukada (RIKEN)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Hirose T, Shimazaki T, Takahashi N, Fukada T, Watanabe T, Tangkawattana P, Takehana K.
Morphometric analysis of thoracic aorta in Slc39a13/Zip13-KO mice.
Cell Tissue Res. (2019) 30610452

Hirose T, Suzuki I, Takahashi N, Fukada T, Tangkawattana P, Takehana K.
Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice.
J. Vet. Med. Sci. (2018) 29563392