Strain Data Sheet

RBRC06137

Strain Information

Image
BRC No.RBRC06137
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameICR.Cg-Tg(TP1-venus)/YsaRbrc
Former Common nameICR-TP1-venus, TP1-venus (ICR)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yumiko Saga, National Institute of Genetics. ICR mixed background.
Strain descriptionTP1-venus transgenic mice. Notch reporter mice, in which venus expression was induced upon activation of Notch signaling via RBP-jk-binding sequence.
Colony maintenanceCarrier x Noncarrier [or Crossing to Jcl:MCH(ICR)]
References
The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis.
Sasaki N, Kiso M, Kitagawa M, Saga Y
Development, 138, 55-64 (2011). 21098559

Visualization of spatiotemporal activation of Notch signaling: live monitoring and significance in neural development.
Kohyama J, Tokunaga A, Fujita Y, Miyoshi H, Nagai T, Miyawaki A, Nakao K, Matsuzaki Y, Okano H
Dev Biol., 286, 311-325 (2005). 16153632

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
VenusYellow Fluorescent Protein (Aequorea victoria)UNVenus12 tandem RBP-J binding site, rBG minimum promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNA12 tandem RBP-J binding site, rBG minimum promoter, Jellyfish venus cDNA, SV40 polyA, pTI(L), pTI(R), HS4 insulator corex2
    Research applicationDevelopmental Biology Research
    Fluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development, 138, 55-64 (2011). Dev Biol., 286, 311-325 (2005). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR/DEVELOPER. The RECIPIENT shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE containing Venus, an acknowledgment to Dr. Atsushi Miyawaki and a citation of the following literature(s) designated by the DEPOSITOR are requested.
    Nat. Biotechnol., 20, 87-90 (2002).
    DepositorYumiko Saga (National Institute of Genetics)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Cui S, Li L, Yu RT, Downes M, Evans RM, Hulin JA, Makarenkova HP, Meech R.
    β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.
    Development 146(6) (2019) 30683662
    Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R.
    Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling.
    Stem Cells 34(8) 2169-82(2016) 27144473