BRC No.RBRC05983
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameICR.Cg-Hes7<tm1Kag>
Former Common nameHes7 KO ; Hes7 KO/lacZ
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Strain developmentDeveloped by Ryoichiro Kageyama, Institute for Virus Research, Kyoto University in 2001. TT2 ES cells were used. The mutant mice were crossed to ICR.
Strain descriptionMost of the coding region was replaced with a IRES-lacZ-PGK-neo cassette. Most homozygous mutant mice die within a few hours of birth.
Colony maintenanceHeterozygote x Wild-type [or Crossing to Slc:ICR]
ReferencesGenes Dev. 2001 15(20):2642-7. 11641270

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Hes7hairy and enhancer of split 7 (Drosophila)11Hes7<tm1Kag>targeted mutation 1, Ryoichiro Kageyama

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Iresinternal ribosomal entry site (EMCV)11

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)11

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)11mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAEMCV (Encephalomyocarditis virus) internal ribosomal entry site (IRES), beta galactosidase (E. coli), mouse phosphoglycerate kinase promoter (PGK promoter), Neo (E. coli), mouse Hes7 genomic DNA
Research applicationFluorescent Proteins/lacZ System
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev. 2001 15(20):2642-7.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT of BIOLOGICAL resource shall obtain a prior written consent on use of it from the DEPOSITOR Dr. Ryoichiro Kageyama (E-mail: rkageyam@virus.kyoto-u.ac.jp ). (No approval form (Form D) is necessary).
DepositorDrs. Itaru Imayoshi and Ryoichiro Kageyama (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data