Strain Data Sheet

RBRC05978

Strain Information

Image
BRC No.RBRC05978
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Mybbp1a<tm1Jyan>
Former Common nameMYBBP1A-KO, B6-Mybbp1a KO
H-2 Haplotype
ES Cell lineiTL BA1[(C57BL/6N x 129S6/SvEvTac)F1]
Background strain
Appearance
Strain developmentDeveloped by Jun Yanagisawa, Graduate School of Life and Environmental Sciences. iTL BA1 ES cells were used. The mutant mice were crossed to C57BL/6J mice over 8 times.
Strain descriptionMYBBP1A gene knockout mice. Exons 1 to 9 were removed. Homozygous mutant mice are embryonic lethal.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
Kuroda T, Murayama A, Katagiri N, Ohta Y M, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, Yanagisawa J
EMBO J., 30, 1054 - 1066 (2011) . 21297583

MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.
Akaogi K, Ono W, Hayashi Y, Kishimoto H, Yanagisawa J
BMC Cancer, 13:65 (2013). doi: 10.1186/1471-2407-13-65. 23388179

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frtyeast FRT (flippase recombination target) site11Frt
Mybbp1aMYB binding protein (P160) 1a11Mybbp1atargeted mutation 1, Jun Yanagisawa
loxPphage P1 loxP11loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 LoxP, Saccharomyces cerevisiae FRT, mouse Mybbp1a genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorJun Yanagisawa (University of Tsukuba)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data