RBRC05975
Information1 | |
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| Image | |
| BRC No. | RBRC05975 |
| Type | Transgene and Spontaneous Mutation |
| Species | Mus musculus |
| Strain name | B6.Cg-Tg(Mt1-RET)242Ina Hr<hr> |
| Former Common name | HL-RET-mice (242line) |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Developed by Masashi Kato, Nagoya University Graduate School of Medicine. Generated by crossing of RET mice and Hr mice (Hos:HRM). The mice were backcrossed to C57BL/6 over 10 times. |
| Strain description | Mt1-Ret 242 mice with hairless mutant. The mice express the human RET under the control of the mouse MT1 promoter/enhancer. Mt1-RET homozygous mutant mice are embryonic lethal. |
| Colony maintenance | Tg: Carrier x Noncarrier; hr: Homozygote x Homozygote |
| References | EMBO J., 10, 3167-3175 (1991). 1915289 J. Invest. Dermatol., 127, 1244-1249 (2007). 17159911 |
Health Report | |
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| Examination Date / Room / Rack | 2016/11/28Room:4-CRack:J 2016/09/26Room:4-CRack:J 2016/07/25Room:4-CRack:J 2016/05/30Room:4-CRack:J 2016/03/28Room:4-CRack:J 2016/01/25Room:4-CRack:J 2015/11/30Room:4-CRack:J 2015/09/28Room:4-CRack:J |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter RETret proto-oncogene (human)UNRETmouse Metallothionein-I promoter-enhancer Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 splicing signal-polyadenylation siteUN |
Information2 | |
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| Donor DNA | Mus musclus Metallothionein-I promoter-enhancer, Homo sapiens RFP/RET cDNA, SV40 splicing signal-polyadenylation site, vector sequence |
| Research application | Cancer Research Dermatology Research Mouse Models for Human Disease |
| Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
| Depositor | Masashi Kato (Chubu University) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
| Additional Info. | |
BRC mice in Publications |
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| No Data |