RBRC05975

Information1

Image
BRC No.RBRC05975
TypeTransgene and Spontaneous MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Mt1-RET)242Ina Hr<hr>
Former Common nameHL-RET-mice (242line)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Masashi Kato, Nagoya University Graduate School of Medicine. Generated by crossing of RET mice and Hr mice (Hos:HRM). The mice were backcrossed to C57BL/6 over 10 times.
Strain descriptionMt1-Ret 242 mice with hairless mutant. The mice express the human RET under the control of the mouse MT1 promoter/enhancer. Mt1-RET homozygous mutant mice are embryonic lethal.
Colony maintenanceTg: Carrier x Noncarrier; hr: Homozygote x Homozygote
ReferencesEMBO J., 10, 3167-3175 (1991). 1915289
J. Invest. Dermatol., 127, 1244-1249 (2007). 17159911

Health Report

Examination Date / Room / Rack2016/11/28Room:4-CRack:J
2016/09/26Room:4-CRack:J
2016/07/25Room:4-CRack:J
2016/05/30Room:4-CRack:J
2016/03/28Room:4-CRack:J
2016/01/25Room:4-CRack:J
2015/11/30Room:4-CRack:J
2015/09/28Room:4-CRack:J

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Hrhairless14Hr<hr>hairless

Gene symbolGene nameChr.Allele symbolAllele namePromoter
RETret proto-oncogene (human)UNRETmouse Metallothionein-I promoter-enhancer

Gene symbolGene nameChr.Allele symbolAllele namePromoter
SV40 splicing signal-polyadenylation siteUN

Information2

Donor DNAMus musclus Metallothionein-I promoter-enhancer, Homo sapiens RFP/RET cDNA, SV40 splicing signal-polyadenylation site, vector sequence
Research applicationCancer Research
Dermatology Research
Mouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorMasashi Kato (Chubu University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data