RBRC05954

Information1

Image
BRC No.RBRC05954
TypeTargeted Mutation and Chromosomal AberrationCartagena
SpeciesMus musculus
Strain nameB6.129S7-Dp(7Herc2-Mkrn3)1Taku
Former Common nameB6-Dp(7C)
H-2 Haplotype
ES Cell lineAB2.2 [129S7/SvEvBrd-Hprt<b-m2>]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Toru Takumi, Osaka Bioscience Institute and Allan Bradley, The Wellcome Trust Sanger Institute in 2004. The mutant mice were backcrossed to C57BL/6J over 20 times.
Strain descriptionChromosome-engineered mouse strain having a 6.3 Mb duplication of mouse chromosome 7 mirroring the human chromosome 15q11-13 duplication.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesCell, 137, 1235-1246 (2009). 19563756

Health Report

Examination Date / Room / Rack2016/03/28Room:4-ARack:E
2016/01/25Room:4-ARack:E
2016/01/06Room:4-ARack:E
2016/01/04Room:4-ARack:E
2015/11/30Room:4-ARack:E
2015/10/07Room:4-ARack:E
2015/10/05Room:4-ARack:E
2015/09/28Room:4-ARack:E

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Herc2HECT and RLD domain containing E3 ubiquitin protein ligase 27Herc2

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Mkrn3makorin, ring finger protein, 37Mkrn3

Gene symbolGene nameChr.Allele symbolAllele namePromoter
HPRThypoxanthine guanine phosphoribosyl transferase (human)7HPRT

Gene symbolGene nameChr.Allele symbolAllele namePromoter
aagouti7aK14 promoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP7loxP

Information2

Donor DNAhuman HPRT genomic DNA, human Keratin14 genomic DNA, mouse Agouti genomic DNA, mouse Tyrosinase genomic DNA, Phage P1 loxP site
Research applicationCre/loxP system
Developmental Biology Research
Mouse Models for Human Disease
Neurobiology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
DepositorToru Takumi (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Apr 2015

BRC mice in Publications

No Data