Strain Data Sheet

RBRC05946

Strain Information

Image
BRC No.RBRC05946
TypeCongenic
SpeciesMus musculus
Strain nameNOD.Cg-H2<d>
Former Common nameNOD.B10D2, NOD-H2<d>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dy Hidenobu Senpuku, National Institute of Infectious Diseases. MHC class II H2<g7> of NOD/LtJ was replaced to H2<d> by crossing with B10.D2 mice. The mice were backcrossed to NOD/LtJ for 9 times.
Strain descriptionNOD MHC Class II H2<d> congenic strain. The congenic mice show no diabetes but develop dry mouth.
Colony maintenanceHomozygote x Homozygote
References
Establishment of an animal model using recombinant NOD.B10.D2 mice to study initial adhesion of oral streptococci.
Abdus Salam M, Matsumoto N, Matin K, Tsuha Y, Nakao R, Hanada N, Senpuku H
Clinical Diagnostic Laboratory Immunology, 11, 379-386 (2004). 15013991

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
H2histocompatibility-2, MHC17H2d variant

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell differentiation(MP:0002145)

  • abnormal cytokine secretion(MP:0003009)

  • abnormal liver physiology(MP:0000609)

  • decreased hematocrit(MP:0000208)

  • decreased susceptibility to parasitic infection(MP:0005026)
    • more 1 phenotypes
  • increased autoantibody level(MP:0003725)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHidenori Senpuku (National Institute of Infectious Diseases)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data