BRC No.RBRC05943
SpeciesMus musculus
Strain nameB6.Cg-Tg(Mt1-RET)242Ina Tg(Dct-LacZ)A12Jkn
Former Common name242RET;Dct-LacZ
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Masashi Kato, Nagoya University Graduate School of Medicine. Generated by crossing of RET mice and Hr mice (Hos:HRM). The mice were backcrossed to C57BL/6 over 10 times.
Strain descriptionMt1-RET/Dct-lacZ Tg mice. These mice express the lacZ in melanocytes under the control of Dct promoter and the human RET under the control of the mouse MT1 promoter/enhancer. Mt1-RET homozygous mutant mice are embryonic lethal.
Colony maintenanceMt1-RET: Carrier x Noncarrier; Dct-lacZ: Carrier x Carrier (Homozygote x Homozygote)
ReferencesDev. Biol., 192, 99-107(1997). 9405100
EMBO J., 10, 3167-3175 (1991). 1915289

Health Report

Examination Date / Room / Rack2020/03/30Room:4-CRack:A


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
RETret proto-oncogene (human)UNRETmouse metallothionein-I promoter-enhancer

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)UNmouse Dct promoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
SV40 splicing signal-polyadenylation site, vector sequenceUN


Donor DNAHomo sapiens RFP/RET cDNA, Mus musclus Metallothionein-I promoter-enhancer, SV40 splicing signal-polyadenylation site, vector sequence, Escherichia coli LacZ, Mus musuculus Dct promoter
Research applicationCancer Research
Dermatology Research
Fluorescent Proteins/lacZ System
Mouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorMasashi Kato (Chubu University)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data