Strain Data Sheet

RBRC05938

Strain Information

Image
BRC No.RBRC05938
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Aicda*dME-cre,-CD2)1Hon
Former Common nameB6.Tg(Aicda-cre)dME, dMe-ac-cre
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tasuku Honjo, Graduate School of Medicine. Kyoto University in 2010.
Strain descriptiondME-ac-cre transgenice mice, in which the region 2 c-Myb- and E2F-binding sites-the silencing elements- in the Aicda enhancer were deleted.
Colony maintenanceCarrier x Noncarrier [C57BL/6NCrSlc]
References
In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression.
Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H
PLoS One, 8, e61433 (2013). 23613851

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
SV40 polyA signalUN
  • hyper-IgM syndrome type 2(MedGEN)
    • CD2CD2 (human)UNCD2
  • hyper-IgM syndrome type 2(MedGEN)
    • Frtyeast FRT (flippase recombination target) siteUNFrt
  • hyper-IgM syndrome type 2(MedGEN)
    • Frtyeast FRT (flippase recombination target) siteUNFrt
  • hyper-IgM syndrome type 2(MedGEN)
    • Iresinternal ribosomal entry site (EMCV)UN
  • hyper-IgM syndrome type 2(MedGEN)
    • crePhage P1 Cre recombinaseUNcremouse Aicda promoter
  • hyper-IgM syndrome type 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Aicda genomic DNA,human CD2 cDNA, Phage P1 Cre, SV40 polyA signal, yeast FRT site, EMCV internal ribosomal entry site (ires)
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One, 8, e61433 (2013).The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data