RBRC05913

Information1

Image
BRC No.RBRC05913
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6N-Tg(CAG-anti-Adipo)1Shb
Former Common nameC57BL/6-TgN(anti-Adipo), Adiponectin antisense Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrSlc
Appearance
Strain developmentDeveloped by Kiyomi Saito, School of Pharmaceutical Sciences, Showa University in 2005. The transgene was injected into the pronuclei of C57BL/6 fertilized eggs.
Strain descriptionAdiponectin antisense transgenic mice. AS compared to the WT mice, the adiponectin level of antisense Tg mice is reduced. In the Tg mice, more severe inflammations are induced in DDS-induced colitis and collagen-induced arthritis compare to the WT mice.
Colony maintenanceCarrier x Carrier [or Crossing to C57BL/6NCrSlc]
ReferencesBiochim. Biophys. Acta, 1761, 709-716 (2006). 16815093

Health Report

Examination Date / Room / Rack2016/04/18Room:3-BRack:B
2016/02/15Room:3-BRack:B
2015/12/14Room:3-BRack:B
2015/10/19Room:3-BRack:B
2015/08/17Room:3-BRack:B
2015/06/15Room:3-BRack:B
2015/04/20Room:3-BRack:B
2015/02/16Room:3-BRack:B

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Adipoqadiponectin, C1Q and collagen domain containingUNAdipoqCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Information2

Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), Mouse Adiponectin cDNA
Research applicationDiabetes and Obesity Research
Immunology and Inflammation Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochim. Biophys. Acta., 1761, 709-716 (2006).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR/DEVELOPER using the Approval Form. The RECIPIENT of BIOLOGICAL RESOURCE agrees to include the DEPOSITOR and the colleague as co-authors in first publication of the results obtained by use of the BIOLOGICAL RESOURCE. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorYasuko Nakano (Showa University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data