Strain Data Sheet


Strain Information

BRC No.RBRC05885
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Vdr<tm1Ska>
Former Common nameB6-Vdr KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Strain developmentDeveloped by Dr. Shigeaki Kato, Institute of Molecular and Cellular Biosciences, University of Tokyo. C57BL/6 and CBA mixed.
Strain descriptionVitamin D receptor gene knockout mice. 1.1kb region containing exon 2 of Vdr was replaced with a neomycin resistance cassette. Homozygous mutant mice show vitamin D dependent rickets type II.
Colony maintenanceHeterozygote x Wild-type
ReferencesEndocrinology, 141, 1317-1324 (2000). 10746634
Nat. Genet., 16, 391-396 (1997). 9241280

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Vdrvitamin D receptor15Vdr<tm1Ska>targeted mutation 1, Shigeaki Kato

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)15neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

Donor DNAmouse phosphoglycerate kinase (PGK) genomic DNA, E. coli neo, mouse Vdr genomic DNA
Research applicationDevelopmental Biology Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Genet., 16, 391-396 (1997).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Dr. Shigeaki Kato,
DepositorKou-ichi Jishage (Chugai Pharmaceutical Co., Ltd.)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data