RBRC05667

Information1

Image
BRC No.RBRC05667
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB10.Cg-H2<k> Tg(H2-Ea-Cd74/MCC)37GNnak
Former Common nameIi-MCC, B10.BR-Ii-MCC Tg#37
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Naoko Nakano, Institute of Genetics and Molecular and Cellular Biology in 1996. Transgene was injected into the pronuclei of (C57BL/6 x SJL) F2 fertilized eggs. The mice were backcrossed to B10.BR over 10 times.
Strain descriptionIi-MCC transgenic mice expressing a fusion protein of Cd74 (MHC II invariant chain) and sequence encoding 88-103 peptides of moth cytochrome c (MCC).
Colony maintenanceCarrier x Noncarrier [or Crossing to B10.BR/SgSnSlc]
ReferencesInt. Immunol., 14, 857-865 (2002). 12147622
Proc. Natl. Acad. Sci. USA, 107, 20453-20458 (2010). 21059929

Health Report

Examination Date / Room / Rack2016/08/22Room:3-BRack:K
2016/06/20Room:3-BRack:K
2016/05/16Room:3-BRack:K
2016/04/18Room:3-BRack:K
2016/02/15Room:3-BRack:K
2015/12/14Room:3-BRack:K
2015/10/19Room:3-BRack:K
2015/08/17Room:3-BRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
H2histocompatibility-2, MHC17H2<k>k variant

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tg(H2-Ea-Cd74/MCC)37GNnakUNTg(H2-Ea-Cd74/MCC)37GNnaktransgene insertion 37G, Naoko Nakano

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)UNCd74mouse MHC class II E alpha promoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
MCCMoth cytochrome CUNMCC

Information2

Donor DNAmouse MHC class II E alpha promoter, mouse MHC class II invariant chain (Cd74), moth Moth cytochrome C (88-103 peptides), rabbit beta-globin polyA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. Immunol., 14, 857-865 (2002).
DepositorNaoko Nakano (Tokyo University of Science)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data