RBRC05652

Information1

Image
BRC No.RBRC05652
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(alpha-MHC/miR143/145)9
Former Common nameB6-aMHC/miR143/145 Tg#9
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Takashi Iwamoto, College of Life and Health Sciences, Chubu University in 2010. The transgene was injected into the (C57BL/6 x BALB/c)F2 fertilized eggs. The mice were crossed to C57BL/6J over 5 generations.
Strain descriptionTransgenic mice expressing miR-143 and miR-145 in cardiomyocytes. Their hearts generally show low %FS after 2 months old and become enlarged.
Colony maintenanceCarrier x Noncarrier [C57BL/6J(Crlj)]Tg mice show a high incidence of sudden death after 2-3 months old.
ReferencesNature, 460, 529-533 (2009). 19626115
Biochem. Biophys. Res. Commun., 372, 856-861 (2008). 18533106

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
miR143pri-miR-143 (human)UNmiR143rat alpha-myosine heavy chain promoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
miR145pri-miR-145 (human)UNmiR145

Information2

Donor DNAMouse Alpha-myosin heavy chain promoter, Homo sapiens pri-miR-143, Homo sapiens pri-miR-145, Homo sapiens Growth hormone polyA signal
Research applicationCardiovascular Research
Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested (will be announced). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval form the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from use of the BIOLOGICAL RESOURCE.
DepositorTakashi Iwamoto (Chubu University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data