RBRC05553

Information1

Image
BRC No.RBRC05553
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Pmaip1<tm1Ttg>
Former Common nameB6-Noxa KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Tsukasa Shibue and Tadatsugu Taniguchi, Graduate School of Medicine, University of Tokyo in 2003. E14.1 ES cell derived. The mutant mice were backcrossed to C57BL/6J.
Strain descriptionNoxa (Pmaip1) gene knockout mice. A 2.4 kb genomic region including exons 1 and 2 of the Pmaip1 gene was replaced with a neomycin selection cassette. Homozygous mutant mice are resistant to X-ray irradiation-induced gastrointestinal death.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesGenes Dev., 17, 2233-2238 (2003). 12952892

Health Report

Examination Date / Room / Rack2013/05/13Room:2-3Rack:C
2013/03/04Room:2-3Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Pmaip1phorbol-12-myristate-13-acetate-induced protein 118Pmaip1<tm1Ttg>targeted mutation 1, Tadatsugu Taniguchi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)18

Information2

Donor DNAE. coli Neomycin resistance gene
Research application
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE and shall limit the use within the scope of the purpose described in this Agreement. The RECIPIENT shall inform the DEPOSITOR about the results obtained by the use of the BIOLOGICAL RESOURCE.
DepositorTadatsugu Taniguchi (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data