RBRC05537

Information1

Image
BRC No.RBRC05537
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC3H.C3B6-Tg(HIV NL4-3dPol)1607Yiw
Former Common nameC3-HIV/NL43dPol Tg#1607
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1992. Transgene was injected into the pronuclei of B6C3F1 fertilized eggs. C3H background.
Strain descriptionTransgenic mice having a NL4-3 region of human immunodeficiency virus (HIV). C3H background. HIV gRNA (non-infectious) is produced in several organs. Tg mice show decreased body weight and cataract with aging.
Colony maintenanceCarrier x Noncarrier [or Crossing to C3H/HeNSlc]
ReferencesAIDS, 6, 1069-1075 (1992). 1466838

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
HIVhuman immunodeficiency virusUNHIV

Information2

Donor DNA11.5 kb BglI-NcoI fragment derived from pNL4-3-2 (The fragment consists of the entire defective HIV proviral genome (9.4 kb: KpnI fragment deletion, nucleotide number 3826-4154)), the cellular franking sequence (2.0 kb), and the bacterial vector sequence (57 bp).)
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsPlease obtain the written consent from Professor Yoichiro Iwakura(iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science)for the use.
DepositorYoichiro Iwakura (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data