Strain Data Sheet

RBRC05511

Strain Information

Image
BRC No.RBRC05511
TypeInbred
SpeciesMus musculus
Strain nameC57BL/10ScSn
Former Common nameB10ScSn
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentMaintained by Gris Galanos, Max-Planck-Institut for Immunobiologie.
Strain descriptionControl strain (wild-type) for C57BL/10ScCr and C57BL/10ScNCr (defective response to LPS stimulation).
Colony maintenanceSibling x Sibling
References
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
A Poltorak, X He, I Smirnova, M Y Liu, C Van Huffel, X Du, D Birdwell, E Alejos, M Silva, C Galanos, M Freudenberg, P Ricciardi-Castagnoli, B Layton, B Beutler
Science, 282, 2085-2088 (1998). 9851930

A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
A Poltorak, T Merlin, P J Nielsen, O Sandra, I Smirnova, I Schupp, T Boehm, C Galanos, M A Freudenberg
J. Immunol., 167, 2106-2111 (2001). 11489994

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal NK cell physiology (MP:0010766)

  • increased susceptibility to bacterial infection (MP:0002412)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHiroaki Takimoto (Kitasato University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data