Strain Data Sheet

RBRC05509

Strain Information

Image
BRC No.RBRC05509
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Trpm1<tm1Tfur>
Former Common name
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain
Appearance
Strain developmentDeveloped by Takahisa Furukawa, Osaka Bioscience Institute in 2005. A neomycin selection cassette was inserted into the exon 4-6 of the TRPM1 gene. C57BL/6 background. 129 background (RBRC05138), B6 background (RBRC05509).
Strain descriptionTrpm1 knockout mice. A neomycin selection cassette was inserted into the exon 4-6 of the TRPM1 gene.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJmsSlc]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Trpm1
MGI:1330305		transient receptor potential cation channel, subfamily M, member 17Trpm1<tm1Tfur>
MGI:4421441		targeted mutation 1, Takahisa Furukawa
  • congenital stationary night blindness 1C(MedGEN)

  • congenital stationary night blindness(DisGeNET)
    • neo neomycin resistance gene (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)
    SV40 polyA signal7

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal amacrine cell morphology (MP:0005240)

  • abnormal cone electrophysiology (MP:0004022)

  • abnormal long-term object recognition memory (MP:0002801)

  • abnormal optokinetic reflex (MP:0009619)

  • abnormal retina rod bipolar cell morphology (MP:0006074)
    • more 7 phenotypes
  • abnormal rod electrophysiology (MP:0004021)

  • absent b-wave (MP:0020439)

  • decreased anxiety-related response (MP:0001364)

  • decreased dopamine level (MP:0005643)

  • decreased noradrenaline level (MP:0012574)

  • hyperactivity (MP:0001399)

  • increased brain weight (MP:0002176)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse PGK promoter, E. coli Neomycin resistance gene, SV40 PolyA signal
    Research applicationMouse Models for Human Disease
    Sensorineural Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
    DepositorTakahisa Furukawa (Osaka Bioscience Institute)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data