RBRC05498

Information1

Image
BRC No.RBRC05498
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Samd9l<tm1Homy>
Former Common nameTITAN KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6NCrlCrlj
Appearance
Strain developmentDeveloped by Hiroaki Honda, Research Institute for Radiation Biology and Medicine, Hiroshima University in 2006. E14 ES cells (129P2/OlaHsd) were used. The mutant mice were crossed to C57BL/6N mice.
Strain descriptionSamd9L knockout mice. A part of Exon 2 of Samd9L gene was replaced with a lacZ-loxP-neo-loxP cassette. Homozygous mutant mice are viable and fertile.
Colony maintenanceHeterozygote x Wild-type [C57BL/6NCrlCrlj]
ReferencesCancer Cell, 9;24(3):305-17 (2013). 24029230
J. Invest. Dermatol., 131, 1428-1434 (2011). 21412262
Biochem. Biophys. Res. Commun., 383, 245-251 (2009). 19358830
Am. J. Hum. Genet., 79, 759-764 (2006). 16960814

Health Report

Examination Date / Room / Rack2013/03/04Room:2-3Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Samd9lsterile alpha motif domain containing 9-like6Samd9l <tm1Homy>targeted mutation 1, Hiroaki Honda

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)6

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)6herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAE. coli lacZ, poly A, Phage P1 loxP sites, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Samd9l genomic DNA
Research applicationCre/loxP system
Fluorescent Proteins/lacZ System
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHiroaki Honda (Tokyo Women's Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

No Data