RBRC05456

Information1

Image
BRC No.RBRC05456
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSTOCK Dab1<yot>
Former Common nameyotari
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentArose in the descendants of a male chimeric mouse (chimera of 129 and C57BL/6JJcl) during the generation of P3R knockout mice.
Strain descriptionYotari mice, spontaneous and autosomal recessive mutant. Homozygous mutant mice show unstable gait and whole-body tremor due to hypoplastic cerebellum. This mutation was caused by a replacement of Dab1 gene sequence with a long interspersed nuclear element (L1) fragment.
Colony maintenanceHeterozygote x Wild-type Homozygous mice exhibit ataxia.
ReferencesNeurosci. Res., 29, 217-223 (1997). 9436647
Brain Res. Mol. Brain Res., 75, 121-127 (2000). 10648895

Health Report

Examination Date / Room / Rack2016/12/05Room:3-5Rack:D
2016/10/03Room:3-5Rack:D
2016/08/08Room:3-5Rack:D
2016/06/20Room:3-5Rack:D
2016/06/20Room:3-5Rack:D
2016/06/06Room:3-5Rack:D
2016/04/04Room:3-5Rack:D
2016/02/01Room:3-5Rack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Dab1disabled homolog 1 (Drosophila)4Dab1<yot>yotari

Information2

Donor DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Brain. Res. Mol. Brain Res., 75, 121-127 (2000). および Neurosci. Res., 29, 217-223 (1997).
DepositorKazunori Nakajima (Keio University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data