Strain Data Sheet

RBRC05426

Strain Information

Image
BRC No.RBRC05426
TypeTransgeneCartagena
SpeciesMus musculus
Strain name129.B6C3-Tg(Crx-cre)1Tfur
Former Common name129-Crx-cre Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Takahisa Furukawa, Osaka Bioscience Institute in 2003. The transgene was injected into the B6C3F1 fertilized eggs. The transgenic mice were backcrossed to 126S6 mice over 6 generations.
Strain descriptionThis transgenic mouse expresses Cre recombinase gene in retinal photoreceptor cells and progenitor cells under the control of the 12-kb mouse Crx promoter.
Colony maintenanceCarrier x Noncarrier [or Crossing to 129S6/SvEvTac]
References
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development.
Nishida A, Furukawa A, Koike C, Tano Y, Aizawa S, Matsuo I, Furukawa T
Nat. Neurosci., 6, 1255-1263 (2003). 14625556

Health Report

Examination Date / Room / Rack2024/05/27Room:4-CRack:JSentinel mouse program
2024/02/26Room:4-CRack:JSentinel mouse program
2023/11/27Room:4-CRack:JSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
cre Phage P1 Cre recombinaseUNcre<Tg(Crx-cre)1Tfur>
MGI:3608904		transgene insertion 1, Takahisa Furukawamouse Crx promoter
SV40 polyA signalUN

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • obsolete no phenotypic analysis (MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Crx genomic DNA (BAC clone), P1 Phage Cre recombinase, SV40 PolyA signal
    Research applicationCre/loxP system
    Sensorineural Research
    Cre driver
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Neurosci., 6, 1255-1263 (2003). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
    DepositorTakahisa Furukawa (Osaka Bioscience Institute)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Rohde K, Bering T, Furukawa T, Rath MF.
    A modulatory role of the Rax homeobox gene in mature pineal gland function: Investigating the photoneuroendocrine circadian system of a Rax conditional knockout mouse.
    J Neurochem 143(1) 100-111(2017) 28675567