BRC No.RBRC05386
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129P2(B6)-Traf6<tm1Jino>
Former Common nameBALB-Traf6 KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Strain developmentDeveloped by Jun-ichiro Inoue, Institute of Medical Science, University of Tokyo in 1999. BALB/c background.
Strain descriptionTraf6 knockout mice. A 2.5 kb genomic fragment was replaced with a neomycin selection cassette. Homozygous mutant mice exhibit severe osteopetrosis and abnormal immune cell development and function, and die within around 2 weeks after birth. Homozygous mice represented only 12% of offspring. C57BL/6 background (RBRC04950), BALB/c background (RBRC05386).
Colony maintenanceHeterozygote x Wild-type [BALB/cAJcl]
ReferencesGenes Cells., 4, 353-362 (1999). 10421844
Science, 308, 248-251 (2005). 15705807

Health Report

Examination Date / Room / Rack2013/05/20Room:4-BRack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Traf6TNF receptor-associated factor 62Traf6<tm1Jino>targeted mutation 1, Jun-ichiro Inoue

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)2mouse Polr2a promoter


Donor DNAmouse Polr2a promoter, E. coli Neomycin resistance gene, SV40 PolyA signal, mouse Traf6 genomic DNA
Research application
Specific Term and Conditions1. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
2. RECIPIENT must contact the DEPOSITOR in the case of application for any patents,any manuscripts, any public presentation,or commercial use, based on the results from the use of the BIOLOGICAL RESOURCE.
3. RECIPIENT must not yield the BIOLOGICAL RESOURCE to other parties or persons.
DepositorJunichiro Inoue (The University of Tokyo)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Sep 2012

BRC mice in Publications

No Data