Strain Data Sheet

RBRC05362

Strain Information

Image
BRC No.RBRC05362
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Fah<tm1Sia>/Rbrc
Former Common nameFAH(-) (Acc. No. CDB0201K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Shinichi Aizawa, RIKEN Center for Developmental Biology.
Strain descriptionFah, fumarylacetoacetate hydrolase knockout mice.
Colony maintenanceHeterozygote x Wild-type [C57BL/6N]
References
Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.
Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H
Hepatology, 48, 1964-1978 (2008). 18837044

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fahfumarylacetoacetate hydrolase7Fah targeted mutation 1, Shinichi Aizawa
  • tyrosinemia type I(DisGeNET, MedGEN)
    • loxPphage P1 loxP7loxP
  • tyrosinemia type I(DisGeNET, MedGEN)
    • loxPphage P1 loxP7loxP
  • tyrosinemia type I(DisGeNET, MedGEN)
    • neoneomycin resistance gene (E. coli)7mouse phosphoglycerate kinase promoter (PGK promoter)
  • tyrosinemia type I(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase genomic DNA, E.coli neo, mouse Fah genomic DNA
    Research applicationCre/loxP system
    Specific Term and Conditions(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0201K and Web. Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Hepatology. 2008 48(6):1964-78.) (3) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data