Strain Data Sheet

RBRC05261

Strain Information

Image
BRC No.RBRC05261
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameDW/J-Tpst2<grt>/Hkv
Former Common nameDW-grt
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Takeshi Yoshida, Mie University School of Medicine. Maintained by Takashi Agui, Graduate School of Veterinary Medicine, Hokkaido University.
Strain descriptionHypothyroid growth-retarded mouse derived from Snell’s dwarf mouse. Homozygous mutant mice show a delayed pubertal growth and hypothyroidism. Homozygous females are infertile and males show markedly-decreased fertility.
Colony maintenanceHeterozygote X Wild-type
References
A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism.
Nobuya Sasaki, Yayoi Hosoda, Aogu Nagata, Ming Ding, Ji-Ming Cheng, Tomomi Miyamoto, Shinya Okano, Atsushi Asano, Ichiro Miyoshi, Takashi Agui
Mol. Endocrinol., 21, 1713-1721 (2007). 17456791

Female infertility in grt mice is caused by thyroid hormone deficiency, not by insufficient TPST2 activity in the reproductive organs.
Yayoi Hosoda, Nobuya Sasaki, Takashi Agui
J. Vet. Med. Sci., 70, 1043-1049 (2008). 18981659

Hypothyroid phenotype of the Tpst2 mutant mouse is dependent upon genetic background.
Yayoi Hosoda, Nobuya Sasaki, Takashi Agui
Biomed. Res. 31, 207-211 (2010). 20622471

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tpst2
MGI:1309516		protein-tyrosine sulfotransferase 25Tpst2<grt>
MGI:1856891		protein-tyrosine sulfotransferase 2; growth retarded

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal adenohypophysis morphology (MP:0004163)

  • abnormal growth hormone level (MP:0003968)

  • abnormal postnatal growth/weight/body size (MP:0002089)

  • abnormal seminiferous tubule morphology (MP:0002216)

  • azoospermia (MP:0005159)
    • more 6 phenotypes
  • decreased activity of thyroid gland (MP:0003503)

  • decreased circulating thyroxine level (MP:0005478)

  • decreased testis weight (MP:0004852)

  • enlarged adenohypophysis (MP:0008366)

  • postnatal growth retardation (MP:0001732)

  • small seminiferous tubules (MP:0001153)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTakashi Agui (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data