Strain Data Sheet

RBRC05258

Strain Information

Image
BRC No.RBRC05258
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.B6D2-Tg(CAG-Fad24)L4-3HMaim
Former Common nameB6-Fad24 Tg#L4-3H
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Masayoshi Imagawa, Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University in 2006.
Strain descriptionTransgenic mice having a mouse fad24 under control of the CAG promoter.
Colony maintenanceCarrier X Noncarrier [C57BL/6J(Crlj)]
References
Fad24 causes hyperplasia in adipose tissue and improves glucose metabolism.
Johmura Y, Watanabe K, Kishimoto K, Ueda T, Shimada S, Osada S, Nishizuka M, Imagawa M
Biol. Pharm. Bull., 32, 1656-1664 (2009). 19801824

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fad24mouse Factor for adipocyte differentiation 24UNFad24CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased circulating glucose level(MP:0005560)

  • decreased white fat cell size(MP:0009133)

  • increased adiponectin level(MP:0004892)

  • increased epididymal fat pad weight(MP:0009288)

  • increased insulin sensitivity(MP:0002891)
    • more 1 phenotypes
  • increased white fat cell number(MP:0009130)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Factor for adipocyte differentiation 24 (fad24) gene cDNA chicken Beta-actin promoter, rabbit Beta-globin polyA, CMV CMV-IE enhancer
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biol Pharm Bull. 2009 32(10):1656-64. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from Dr.Makoto Nishizuka (nishizuka@hirosaki-u.ac.jp) using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorMasayoshi Imagawa (Nagoya City University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. CAGGS MTA (English)
    5. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data