Strain Data Sheet


Strain Information

BRC No.RBRC05235
SpeciesMus musculus
Strain nameC57BL/6-Tg(TH-ALK*F1174L)9Homy
Former Common nameB6-Th-ALK/F1174L Tg#9L
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Hiroaki Honda, Research Institute for Radiation Biology and Medicine and Junko Takita, The University of Tokyo Hospital. A F1174L mutant hALK gene under the TH promoter was injected into the pronuclei of C57BL/6N fertilized eggs.
Strain descriptionHuman ALK (anaplastic lymphoma kinase) gene having F1174L mutation transgenic mice. F1174L mutation was identified in a patient with an inflammatory myofibroblastic tumor harboring a RANBP2-ALK translocation.
Colony maintenance
ReferencesNature, 455, 971-974 (2008). 18923524

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
ALKhuman ALK cDNA (F1174L mutant)UNALKhuman tyrosine hydroxylase promoter

Ordering Information

Donor DNAhuman tyrosine hydroxylase promoter, human ALK cDNA (F1174L mutant), rabbit beta globin intron, Herpes simplex virus HSV terminator
Research applicationCancer Research
Mouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHiroaki Honda (Tokyo Women's Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)

BRC mice in Publications

No Data